Job Details
Yoh is hiring an Senior Scientist - Disease Biology & Translational Sciences for our S. San Francisco, CA client.
In this role, will be responsible for helping to establish and expand the company s capabilities for preclinical in vivo, in vitro and clinical ex vivo disease pathobiology establishing in vivo, in vitro, and ex vivo models to interrogate complex disease models to rank and screen our therapeutic candidates, and establish the drug s mechanism of action for multiple indications. A successful candidate for this opportunity will have a background in diabetes or obesity research.
Industry: Drug Discovery
Location: S. San Francisco, CA
Compensation: $175k - $200k (based upon experience)
Type: Direct Hire
Key Responsibilities
- Design and execute in vivo, in vitro and ex vivo studies to advance therapeutic programs for diabetes or obesity
- Lead cell based therapeutic characterization and development efforts defining the compounds mechanism of action and efficacy in complex in vivo and in vitro models of disease.
- Lead from the bench managing internal scientists as well as external CROs to execute strategies and be responsible for the development and conduct of in vivo, in vitro, and/or ex vivo studies to support and advance company's drug discovery pipeline.
- Establish pharmacodynamic and efficacy relationships as appropriate to determine the potential clinical impact of company's drugs.
- Serve as the Disease Biology lead on cross-functional research and development teams and have opportunities to lead programs from discovery through early development.
- Generate, analyze, and interpret complex data to establish functional PK/PD and efficacy relationships and elucidate therapeutic mechanism of action for leads drugs
- Help build complex in vivo, in vitro, and ex vivo research and development capabilities
- Author and review protocols, study reports, and regulatory documents to enable IND and other regulatory filings
Education, Skills & Experience
- PhD Endocrinology, Physiology, Diabetes/Obesity, Inflammation, or Metabolic Disease, or related biological science (MSc/BSs with relevant years of experience)
- At least 8 years of direct hands-on experience in therapeutic development leveraging indication-specific functional disease models in biotechnology and pharmaceutical industries
- MUST have experience with therapeutics programs that have yielded drugs entering clinical development in diabetes or obesity
- Experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g. IF/IHC/ISH), and/or flow cytometry
- Ability to be hands-on and work in the lab, manage scientists, write protocols, execute studies leveraging company's in-house capabilities or work with CROs
- Direct experimental experience with complex disease biology of diabetes, obesity or other metabolic disease
- Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays
- Leverage complex data sets to characterize therapeutic leads and establish a drug s therapeutic mechanisms of action
- Experience working on/leading project teams with functional responsibility to propose strategy, analyze, interpret, and present complex data to inform decisions
- Ability to collaborate in writing protocols, reports, and regulatory documents
- Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner
- Experience authoring study protocols, reports, and/or regulatory documents including IBs, IND filings, CSRs, and/or NDAs